CircO2 Nitric Oxide

The Circulation System Resilience: The Performance Protocol 

For the high-performing professional over 55, the body's two most critical and interconnected systems  cardiovascular function and metabolic regulation  do not fail dramatically or suddenly. They decline quietly, gradually, and simultaneously. Blood pressure shifts. Cholesterol balance changes. Blood sugar becomes harder to regulate. Weight accumulates despite consistent effort. Energy becomes less reliable.

These are not separate problems requiring separate solutions. They are one interconnected biological system requiring a unified clinical response.

The MetaVital protocol addresses this system at three distinct levels — circulation, cardiometabolic protection, and hormonal regulation  using three precision-formulated supplements each targeting a specific bottleneck in your cardiovascular and metabolic architecture.

The Science of Nitric Oxide Restoration After 55

Your arteries are not rigid pipes. They are living tissue — capable of relaxing, widening, and constricting in response to biological signals. The primary signal governing this process is Nitric Oxide — a molecule produced by the inner lining of your blood vessels called the endothelium.

When Nitric Oxide levels are healthy, vessels relax and widen on demand. Oxygen-rich blood reaches the brain rapidly during complex cognitive tasks. Muscles receive the circulation they need during physical activity. The heart pumps against lower resistance. Blood pressure remains stable.

After 55, endothelial Nitric Oxide production declines significantly. One study found adults aged 70–80 had lost up to 75% of coronary endothelial Nitric Oxide production compared to healthy 20-year-olds (Source: Egashira et al., cited in Nitric Oxide and Geriatrics, PMC). The consequence is not dramatic or sudden. It is a gradual stiffening of vessels, a quiet reduction in cerebral blood flow, and a progressive increase in cardiovascular workload — experienced as brain fog, physical fatigue, cold extremities, and reduced stamina.

CircO2 is formulated to restore Nitric Oxide availability through a quick-dissolve tablet delivery system that enters the bloodstream faster than standard capsules — providing rapid vascular response rather than delayed absorption.

The Formula — What Each Ingredient Does

• L-Citrulline — An amino acid — a building block of protein — that the body converts into L-Arginine, which is the direct precursor to Nitric Oxide production in the endothelium. L-Citrulline is clinically preferred over L-Arginine itself because it survives digestion more efficiently and produces a more sustained elevation in Nitric Oxide levels

• Beetroot Powder — A concentrated source of dietary nitrates. Nitrates are compounds that the body converts through a separate biological pathway — the nitrate-nitrite-Nitric Oxide pathway — into Nitric Oxide, providing a second independent route to vascular relaxation and oxygen delivery

• Hawthorn Berry — A botanical with decades of clinical research supporting cardiovascular function. Hawthorn supports healthy blood pressure, improves coronary blood flow — meaning circulation directly to the heart muscle — and provides antioxidant protection to vessel walls

• Vitamin B12 (as Methylcobalamin) — The active, most bioavailable form of B12. Supports red blood cell formation — the cells responsible for carrying oxygen through the bloodstream. Healthy red blood cell production ensures that the vessels CircO2 opens are carrying oxygen-rich blood at full capacity

• Magnesium — Essential for vascular smooth muscle relaxation. Magnesium deficiency — extremely common in adults over 55 — is directly associated with elevated blood pressure and impaired vessel flexibility

• Sodium Nitrite — Provides an additional direct source of nitrite, the intermediate compound in the nitrate-to-Nitric Oxide conversion pathway, supporting rapid Nitric Oxide availability particularly in low-oxygen environments such as during physical exertion

• Vitamin C — Protects Nitric Oxide molecules from oxidative degradation — meaning it prevents the free radical damage that would otherwise break down Nitric Oxide before it can act on vessel walls, extending the duration and effectiveness of each dose

Clinical Outcomes

• Restored cerebral blood flow supporting mental clarity, focus, and decision-making speed

• Reduced cardiovascular workload through vessel relaxation and blood pressure support

• Improved physical stamina and reduction in the heavy limb fatigue common after 55

• Sustained Nitric Oxide elevation through dual-pathway activation — both the L-Citrulline and dietary nitrate routes simultaneously

Who This Is For

Adults over 55 experiencing reduced mental sharpness during high-stakes tasks, physical fatigue disproportionate to activity level, cold extremities, or elevated blood pressure. CircO2 does not force the heart to work harder. It restores the biological environment in which the heart works efficiently.

The Synchronization Logic: Open, relaxed vessels are only as effective as the blood flowing through them. CircO2 restores the pathway. Step 2 protects and maintains the cardiometabolic integrity of that pathway over the long term.

Secure Clinical Supply of CircO2 via Digistore24

Deep Dive: Read the Full Technical Deep-Dive on CircO2 Nitric Oxide

Clear Flux: The Cardiometabolic Shield — Why Blood Sugar and Circulation Are the Same Problem After 55

Most professionals over 55 think about cardiovascular health and metabolic health as two separate concerns. One is about the heart. The other is about weight and blood sugar. They see two different doctors, take two different approaches, and treat them as unrelated problems.

Clinical science tells a different story. They are the same problem operating through the same biological system — and after 55, they accelerate each other.

The Cardiometabolic Connection

Your cardiovascular system — the network of heart, blood vessels, and circulation — and your metabolic system — the biological machinery governing blood sugar, insulin, and energy conversion — are not independent. They are deeply interdependent.

Here is how the cycle works. When blood sugar regulation becomes inefficient — meaning glucose levels spike after meals and do not return to baseline smoothly — the excess glucose creates oxidative stress on vessel walls. Oxidative stress is the cellular damage caused by unstable molecules called free radicals. Over time this damages the lining of blood vessels, makes them stiffer, raises blood pressure, and disrupts cholesterol balance.

Conversely, poor cardiovascular circulation means cells receive oxygen and nutrients less efficiently — which impairs the metabolic processes those cells perform, including insulin signaling. The two systems degrade together.

After 55, both sides of this equation weaken simultaneously. Blood sugar regulation becomes less precise. Insulin sensitivity — the efficiency with which cells respond to insulin's signal to absorb glucose — declines. Cholesterol balance shifts. Vessel walls stiffen. Each one makes the other worse.

Clear Flux is formulated to intervene across the full cardiometabolic axis rather than targeting one marker in isolation.

The Formula — What Each Ingredient Does

Clear Flux combines vitamins, minerals, herbal extracts, and metabolic cofactors into a multi-mechanism cardiometabolic support system.

Blood Sugar Regulation

• Banaba Extract (25mg) — Contains corosolic acid, a compound clinically shown to support healthy glucose uptake into cells by activating glucose transport mechanisms, reducing post-meal blood sugar spikes — confirmed in a randomized, double-blinded, placebo-controlled crossover trial in men with impaired fasting glucose.
• Bitter Melon Extract (20mg) Contains compounds that mimic insulin activity and support the body's own glucose regulation pathways — supported by a 12-week randomized, placebo-controlled clinical trial in prediabetic adults showing improved post-meal blood glucose response.
• Gymnema Extract (3mg) Reduces sugar craving signals and supports healthy blood sugar levels by partially blocking intestinal glucose absorption demonstrated in a randomized controlled study where participants reduced their consumption of high-sugar sweet foods after taking Gymnema sylvestre.
• White Mulberry Extract (3mg) — Inhibits the enzyme that breaks down carbohydrates into sugar in the digestive tract, slowing glucose entry into the bloodstream
• Cinnamon Powder (50mg) — Supports insulin sensitivity and smooth post-meal glucose response
• Chromium (67mcg) — A trace mineral essential for insulin function; chromium deficiency directly impairs the body's ability to regulate blood sugar efficiently

Cholesterol and Lipid Metabolism

• Guggul (50mg) — A resin extract studied for cholesterol support, though clinical results have been mixed. Some earlier studies suggested modest benefits for LDL cholesterol (the form associated with arterial buildup when oxidized) versus HDL (the protective form), while a rigorous randomized controlled trial found no significant improvement compared to placebo. We include it as part of this broader formula rather than relying on it as a standalone cholesterol solution.

Cardiovascular and Circulatory Support

• L-Taurine (25mg) — An amino acid — a building block of protein — with strong clinical evidence for supporting healthy blood pressure and protecting heart muscle cell function
• Yarrow Powder (25mg) — A botanical with traditional and emerging clinical use supporting circulatory tone and peripheral blood flow — meaning blood flow to the extremities
• Juniper Extract (13mg) — Supports kidney function and healthy fluid regulation, both of which directly affect blood pressure management
• Cayenne Pepper (10mg) — Contains capsaicin, a compound shown to support healthy circulation and vascular tone

Cellular Protection

• Alpha Lipoic Acid (30mg) — A potent antioxidant — a compound that neutralizes oxidative damage — with specific affinity for both fat-soluble and water-soluble environments, meaning it protects cell membranes and cellular fluid simultaneously. Particularly relevant for protecting vessel walls from glucose-related oxidative stress
• Vitamin C (50mg) and Vitamin E (7mg) — Synergistic antioxidants that protect cardiovascular tissue from free radical damage
• Magnesium (125mg) — One of the most critical minerals for cardiovascular function. Magnesium deficiency is clinically associated with elevated blood pressure, irregular heart rhythm, and impaired insulin sensitivity
• Zinc (8mg) and Manganese (1mg) — Essential trace minerals supporting enzyme function and cellular repair across metabolic and cardiovascular pathways
• Vanadium (2mcg) — A trace element studied for its role in supporting healthy insulin sensitivity and glucose metabolism

What This Means for the 55+ Executive

Clear Flux does not target a single cardiovascular or metabolic marker. It addresses the full biological environment in which cardiometabolic aging occurs — blood sugar precision, cholesterol balance, circulatory tone, vessel wall protection, and kidney function.

For an executive over 55 whose cardiovascular and metabolic systems are under compounding stress from decades of high-output professional life, this multi-mechanism approach reflects the clinical reality: these systems do not fail one marker at a time. They degrade as an interconnected system. They require support as an interconnected system.

This is why Clear Flux functions as Step 2 of the MetaVital protocol. CircO2 in Step 1 restores Nitric Oxide and opens vascular pathways. Clear Flux in Step 2 protects and maintains the metabolic integrity of those pathways. GLP-1 Plus in Step 3 restores the hormonal regulation that governs appetite and long-term metabolic stability. Together they form a complete cardiometabolic resilience protocol.

Secure Clinical Supply of Clear Flux via Digistore24

Deep Dive: Read the Full Technical Deep-Dive on Clear Flux

Why Your Hunger Is Not a Willpower Problem — And What Actually Controls It After 55

There is a particular frustration that many high-performing professionals over 55 share but rarely admit. You have the discipline to run organizations, manage teams, and execute under pressure. Yet controlling what you eat — specifically the hunger and cravings that arrive uninvited — feels like a battle that willpower alone cannot consistently win.

That is not a character flaw. It is a hormonal reality.

The Hormone That Controls Hunger — And What Happens to It After 55

Inside your body is a hormone called GLP-1 — Glucagon-Like Peptide-1. Think of it as your body's internal fullness signal. When you eat, GLP-1 is released by cells in your small intestine and communicates directly with your brain to say: enough, stop eating, you are satisfied.

In a well-functioning metabolic system, GLP-1 keeps appetite proportionate to caloric need. You eat until satisfied, not until overfull. Cravings remain manageable. Blood sugar — the level of glucose circulating in your bloodstream — stays stable between meals rather than spiking and crashing.

After 55, GLP-1 signaling weakens. The gut releases less of it. The brain responds to it less efficiently. The result is a hormonal gap where your fullness signals arrive late, quietly, or not at all — and your appetite operates without adequate biological regulation. This is why portion control becomes progressively harder with age despite no change in self-discipline.

It is also why GLP-1 prescription drugs have become one of the fastest-growing pharmaceutical categories globally. They work precisely because they restore this signaling pathway artificially.

The Natural Alternative — GLP-1 Plus

GLP-1 Plus from Advanced Bionutritionals takes a different approach. Rather than introducing a synthetic hormone via injection, it uses four clinically studied natural compounds to support your body's own GLP-1 production and appetite regulation mechanisms.

GlucoVantage DHB (Dihydroberberine) — 200mg

The flagship ingredient. Berberine is a plant-derived alkaloid — a naturally occurring compound found in several plants — with decades of research supporting its role in blood sugar and metabolic regulation. The problem with standard berberine is poor absorption. Your body converts it into a metabolite called DHB — dihydroberberine — and it is actually the DHB that does the biological work.

GlucoVantage is a patented form of DHB that bypasses that conversion entirely, delivering the active compound directly. The result is absorption five times greater than standard berberine. In preclinical research from the ingredient manufacturer, GlucoVantage was linked to a 95% increase in GLP-1 hormone levels, and when combined with exercise a 22.7% greater reduction in fat mass, 15.7% greater lean muscle preservation, and a 34.2% reduction in oxidative stress markers linked to faster recovery, compared to exercise alone (Source: NNB Nutrition preclinical research, summarized by PricePlow). A registered human clinical trial is currently underway studying DHB's effects on GLP-1 levels in adults with pre-diabetes.

Gymnema Sylvestre

A botanical used in traditional wellness practice for centuries and now validated in modern research. Gymnema works on a specific mechanism: it reduces the intensity of sugar cravings by partially blocking sweet taste receptors and lowering the brain's desire response to sugar. In controlled studies, participants given Gymnema consumed significantly less of their favorite sweets compared to placebo groups — not because of willpower, but because the biological craving signal was quieter.

Ceylon Cinnamon Bark Extract — 100mg

Supports healthy blood sugar response after meals. Stable post-meal blood sugar — meaning glucose levels that rise moderately and return to baseline smoothly — directly reduces the energy crashes and subsequent hunger spikes that drive overeating in the hours after eating.

Chromium Picolinate — 100mcg

Chromium is a trace mineral — required by the body in small amounts — that supports insulin sensitivity. Insulin is the hormone responsible for moving glucose from the bloodstream into cells for energy. When insulin sensitivity declines, blood sugar becomes harder to regulate and hunger signals become erratic.

What This Means for the 55+ Executive

The four compounds in GLP-1 Plus target appetite dysregulation from multiple biological angles simultaneously: GLP-1 hormone support, craving reduction, post-meal blood sugar stability, and insulin sensitivity. This is not a stimulant-based appetite suppressant. It does not create dependency or artificial energy. It restores the regulatory hormonal environment that governs appetite — the environment that age has progressively disrupted.

For professionals over 55 who maintain active, disciplined lifestyles but find metabolic control increasingly elusive despite consistent effort, GLP-1 Plus addresses the biological cause rather than demanding greater willpower from an already disciplined person.

Deep Dive: Read the Full Technical Deep-Dive on GLP-1 Plus

The Resource Center: Want to Learn More? Read Our Clinical Guides on Metabolic & Heart Health 

The Cognitive Axis: The link between Nitric Oxide and executive cognitive performance

The Science Behind Weight Gain After 50: GLP-1 and Metabolic Slowdown